تعداد اعضاء : 3503 نفر
بازدیدهای امروز :104 بار
تعداد کل بازدیدها : 703035 بار
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Volume: 41
Year: 2019
Month: 9
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| Subject
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Biochemistry
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| Title
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Serum level of PAPPA-A (pregnancy associated plasma protein-A) at first trimesterand its relation with adverse pregnancy outcome
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| Authors
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Bita Yosefi Khangah; Khatere Tooba; Afshan Sharghi;
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| Abstract
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Background: PAPP-A is a preterm marker for undesirable pregnancy diagnosis. The relationship between PAPP-A serum levels and maternal health, especially gestational diabetes, which is the most common outcome of pregnancy, is a major issue that needs to be studied. The aim of this study were to evaluate the serum level of PAPP-A and pregnancy outcomes.
Methods: in this study all pregnant women who referred to the pregnancy care clinics during their first 3 months, serum levels of PAPP-A were evaluated. As their PAPP-A serum level were less than 0.4 Mom, they were considered as risk-positive and pregnant women with a serum PAPP-A level of more than 0.4 MM as a control group. In the subjects, maternal age, serum PAPP-A level, type of delivery, gestational age, intrauterine growth restriction, preeclampsia, spontaneous abortion, and gestational diabetes were evaluated.
Results: The mean age of pregnant women were 26.85 ±4.74 years. There were a significant reverse correlation between serum concentration of first trimesters PAPP-A and preeclampsia (p=0.003), pregnancy Diabetes (p=0.003), restriction of intrauterine growth (p=0.005) and spontaneous abortion (p=0.04), but there were not significant corrections between serum level of PAPP-A with early birth (p=0.102) and gestation type (p=0.583).
Conclusion: A reduced amount of first trimester PAPP-A would used as a probable risk factor in complications of pregnancy or embryo including preeclampsia, Gestational Diabetes, restriction of intrauterine growth and spontaneous abortion.
Keyword: PAPP-A serum level, First trimester of pregnancy, Consequences of pregnancy
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ISSN 1608-5671 (Print)
ISSN 2008-160X (Online)
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